DE-2

Supermodule 1383 genes

Serine/threonine kinase signaling and phosphotransferase activity

This module contains 1,440 genes, including CTNNB1, MTOR, MAPK1, PIK3CA, and MDM2, and is enriched for protein serine/threonine kinase activity, phosphotransferase activity, and kinase activity. Knockdown of CTBP1 activates this module. Knockdown of TCEB3 and ZC3H3 represses this module.

Notable genes: CTNNB1 MTOR MAPK1 PIK3CA MDM2 MAPK14 RB1 LEPR Top TFs: CTBP1 TCEB3 ZC3H3 AATF ADNP

TF Regulatory Network

Direction indicates the effect of TF knockdown on this module (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	#gRNA	padj	Bind	OR

Submodules (47)

Finer-grained co-expression clusters within this supermodule, each with a distinct functional signature.

Submodule	Genes	Notable genes
DE-2.1	84	EP300 FBXW7 CREBBP IGF2BP3 LRP6
DE-2.2	72	TUG1 CSNK1A1 MAT2A SNHG3 KMT2E
DE-2.3	44	CCM2 PLCG1 STK4 CRY1 VAPB
DE-2.4	39	SPAST KRIT1 NCK1 USP8 KDM5A
DE-2.5	30	RB1 LRP5 SMO SKI SSH1
DE-2.6	25	FGF1 CEMIP MSRA OSBP2 SZT2
DE-2.7	23	GNAQ IGF2R MRTFA CELF1 ATXN7
DE-2.8	20	CTNNB1 ACVR1 DIAPH1 CCDC88A SMURF2
DE-2.9	19	CDK6 CLIP1 EEA1 EPS15 GREM2
DE-2.10	19	TMEM67 PRDM10 IQCK ZNF655 ZNF251
DE-2.11	18	ABCC1 TRAF3 NCOR2 NR2C2 DIDO1
DE-2.12	18	SMARCA4 SMAD7 AXIN1 INO80 MARK2
DE-2.13	18	IRS1 SLC16A4 SENP1 TDP1 KIF7
DE-2.14	17	ATG5 REV3L BCL2L14 RBMS1 PPP2R3A
DE-2.15	17	POR CRK SOCS6 CLK1 PPP1R10
DE-2.16	17	IL7 GNE NCOA7 LRP2BP SUSD1
DE-2.17	16	STIM1 PDE5A WWP2 DEPDC5 SLC12A6
DE-2.18	16	LYPLAL1 DMGDH RNF13 TTC8 GDPD1
DE-2.19	15	ITGAV DAPK1 LATS2 EXT1 TEAD1
DE-2.20	15	BTD SYNGAP1 SNX1 CPEB3 WDR35
DE-2.21	15	HNF4A PAX2 SLCO2A1 RIPOR2 SMAP2
DE-2.22	15	LYN SATB2 PAWR TOX3 LAMC1
DE-2.23	14	TOP1 MIR17HG CUL3 YES1 TNPO1
DE-2.24	14	MCPH1 ATXN10 ENOX2 ELP3 EEFSEC
DE-2.25	13	PTPN11 USP10 MED15 METTL16 AGFG1
DE-2.26	13	HULC CHM UVSSA DHTKD1 D2HGDH
DE-2.27	13	ROCK1 CREM HIPK1 FNTB KPNA5
DE-2.28	13	TPD52 ITPR3 DAPK2 L2HGDH SYNJ2
DE-2.29	12	MAPK14 ADAM9 RPS6KA3 RANBP9 LEMD3
DE-2.30	12	FAM120C ZNF565 FAM151B-DT ZBTB47-AS1 ENSG00000259986
DE-2.31	12	MAVS GAK PPP1R13B MAPK8IP3 MYO18A
DE-2.32	12	C5 NFATC1 GDF11 LINC00632 IL17RD
DE-2.33	12	PLXNB1 SEC16A LMAN2L DLGAP4 MAU2
DE-2.34	11	CNOT2 MYSM1 ZDHHC20 PHF3 MBTD1
DE-2.35	11	NCOR1 CUL5 WAPL ORC2 ZNF652
DE-2.36	11	TNKS2 FOXK1 RAB6A ATG14 MORC3
DE-2.37	11	REST STK38 MIA3 UBE2K CLPX
DE-2.38	11	TBK1 DNM1 NFX1 SLCO3A1 SLC10A7
DE-2.39	11	GABBR1 SACS MMP16 RIMS1 DOCK5
DE-2.40	10	PIK3CA MTMR3 RC3H1 WDR26 JMY
DE-2.41	10	ACACA KDM4B GNA12 GNB1 RAPGEF1
DE-2.42	10	ADIPOR2 ARID3B SCYL2 ANKFY1 RAD54L2
DE-2.43	10	MAP3K7 SPOP GNAI1 MARCHF5 USP33
DE-2.44	10	AGK MBTPS1 YTHDC2 GCFC2 SHLD2
DE-2.45	10	ATP7B DNAJC5 POM121 ZC3H7B BLTP3A
DE-2.46	10	THBS4 ATP8B1 CLYBL ENSG00000251654 ENSG00000286980
DE-2.47	10	SPTLC2 CHST15 VPS45 FAM83B DZIP1L

Module Genes

All genes assigned to this co-expression supermodule.

Gene	Type	Submodule	Publications

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).