DE-2

DE-2.25

Submodule 13 genes

Signal transduction and protein modification factors

This module contains 13 genes including PTPN11, USP10, MED15, and METTL16, with enrichment in protein phosphorylation, ubiquitin-dependent protein catabolic processes, and signal transduction. No transcription factor knockdown data are available for this module. The functional roles of these genes suggest involvement in post-translational modification and signaling regulation during endoderm differentiation.


TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding
Perturbation only
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).


Module Genes (13)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z