MYO18A

myosin XVIIIA | KIAA0216, MysPDZ, TIAF1

The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]

Member of: DE-2 DE-2.31

Biological processes 44 terms

ADP binding (GO:0043531)ATP binding (GO:0005524)ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)ATP-dependent activity, acting on DNA (GO:0008094)DNA binding (GO:0003677)DNA metabolic process (GO:0006259)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi organization (GO:0007030)Golgi ribbon formation (GO:0090161)Golgi vesicle budding (GO:0048194)RNA binding (GO:0003723)actin cytoskeleton (GO:0015629)actin filament binding (GO:0051015)actin filament binding (GO:0051015)actomyosin (GO:0042641)actomyosin structure organization (GO:0031032)actomyosin structure organization (GO:0031032)asymmetric Golgi ribbon formation (GO:0090164)canonical NF-kappaB signal transduction (GO:0007249)cell migration (GO:0016477)cell surface (GO:0009986)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)membrane (GO:0016020)microtubule organizing center (GO:0005815)myosin II complex (GO:0016460)myosin complex (GO:0016459)myosin filament (GO:0032982)negative regulation of apoptotic process (GO:0043066)negative regulation of apoptotic process (GO:0043066)negative regulation of apoptotic process (GO:0043066)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of opsonization (GO:1903028)positive regulation of opsonization (GO:1903028)positive regulation of protein secretion (GO:0050714)protein binding (GO:0005515)regulation of macrophage activation (GO:0043030)regulation of macrophage activation (GO:0043030)trans-Golgi network (GO:0005802)

Expression (TPM)

TFs regulating MYO18A 0 TFs

Transcription factors with Perturb-seq knockdown data for MYO18A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYO18A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MYO18A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYO18A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:28,896,962–28,898,028	282.8 kb	Distal (>10kb) Multiome	846
chr17:28,902,302–28,903,488	277.4 kb	Distal (>10kb) Multiome	967
chr17:28,950,281–28,952,708	228.7 kb	Distal (>10kb) Multiome	989
chr17:28,984,463–28,984,954	195.8 kb	Distal (>10kb) Multiome	33
chr17:28,985,971–28,986,457	194.2 kb	Distal (>10kb) Multiome	123
chr17:29,005,841–29,006,414	174.3 kb	Distal (>10kb) Multiome	707
chr17:29,039,928–29,040,500	140.2 kb	Distal (>10kb) Multiome	99
chr17:29,042,531–29,043,259	137.5 kb	Distal (>10kb) Multiome	553
chr17:29,148,688–29,149,641	31.4 kb	Distal (>10kb) Multiome	709
chr17:29,176,562–29,177,220	3.6 kb	Proximal (<10kb) Multiome	782
chr17:29,179,268–29,180,802	957 bp	At TSS Multiome	781
chr17:29,292,464–29,294,599	112.4 kb	Distal (>10kb) Multiome	1029
chr17:29,369,902–29,370,603	189.8 kb	Distal (>10kb) Multiome	305
chr17:29,389,919–29,391,325	209.9 kb	Distal (>10kb) Multiome	863

Genome Browser

Genomic view of the MYO18A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.