Enables ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K11-linked ubiquitination. Located in site of DNA damage. Part of Cul5-RING ubiquitin ligase complex. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CUL5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CUL5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CUL5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:107,833,401–107,834,470 | 174.9 kb | Distal (>10kb) Multiome | 123 | |
| chr11:107,857,895–107,860,083 | 150.0 kb | Distal (>10kb) Multiome | 916 | |
| chr11:107,927,906–107,929,475 | 80.5 kb | Distal (>10kb) Multiome | 653 | |
| chr11:107,999,826–108,000,323 | 8.6 kb | Proximal (<10kb) | 153 | |
| chr11:108,008,534–108,009,915 | 154 bp | At TSS Multiome | 1031 | |
| chr11:108,121,137–108,122,070 | 112.7 kb | Distal (>10kb) Multiome | 878 | |
| chr11:108,221,947–108,224,257 | 214.0 kb | Distal (>10kb) Multiome | 939 | |
| chr11:108,664,315–108,665,549 | 656.1 kb | Distal (>10kb) Multiome HiCAR | 672 |
Genomic view of the CUL5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.