This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for DNAJC5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJC5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJC5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:63,626,480–63,627,647 | 268.1 kb | Distal (>10kb) Multiome | 982 | |
| chr20:63,641,266–63,642,913 | 253.1 kb | Distal (>10kb) Multiome | 691 | |
| chr20:63,652,233–63,654,166 | 241.6 kb | Distal (>10kb) Multiome | 1011 | |
| chr20:63,657,813–63,658,939 | 236.7 kb | Distal (>10kb) Multiome | 1055 | |
| chr20:63,696,254–63,697,070 | 198.6 kb | Distal (>10kb) Multiome | 458 | |
| chr20:63,707,489–63,708,488 | 187.2 kb | Distal (>10kb) Multiome | 1008 | |
| chr20:63,737,573–63,741,470 | 155.5 kb | Distal (>10kb) Multiome | 1098 | |
| chr20:63,775,216–63,775,997 | 119.7 kb | Distal (>10kb) Multiome | 257 | |
| chr20:63,830,341–63,832,721 | 63.8 kb | Distal (>10kb) Multiome | 628 | |
| chr20:63,846,273–63,846,790 | 48.7 kb | Distal (>10kb) Multiome | 487 | |
| chr20:63,864,234–63,865,991 | 30.0 kb | Distal (>10kb) Multiome | 1158 | |
| chr20:63,894,341–63,895,764 | 110 bp | At TSS Multiome | 791 | |
| chr20:63,896,382–63,896,590 | 1.3 kb | Proximal (<10kb) | 474 | |
| chr20:63,938,191–63,939,815 | 43.6 kb | Distal (>10kb) Multiome | 287 | |
| chr20:63,939,918–63,942,008 | 46.5 kb | Distal (>10kb) Multiome | 496 | |
| chr20:63,955,375–63,956,875 | 61.2 kb | Distal (>10kb) Multiome | 1107 | |
| chr20:63,956,976–63,958,127 | 62.5 kb | Distal (>10kb) Multiome | 709 | |
| chr20:63,969,149–63,970,667 | 74.8 kb | Distal (>10kb) Multiome | 764 | |
| chr20:63,973,660–63,974,150 | 78.8 kb | Distal (>10kb) Multiome | 767 | |
| chr20:63,980,541–63,981,488 | 86.0 kb | Distal (>10kb) Multiome | 986 | |
| chr20:64,030,226–64,031,221 | 135.6 kb | Distal (>10kb) Multiome | 159 | |
| chr20:64,038,338–64,039,469 | 144.0 kb | Distal (>10kb) Multiome | 628 | |
| chr20:64,047,989–64,049,987 | 154.4 kb | Distal (>10kb) Multiome | 541 | |
| chr20:64,053,902–64,054,682 | 159.1 kb | Distal (>10kb) Multiome | 609 | |
| chr20:64,057,481–64,058,099 | 162.8 kb | Distal (>10kb) Multiome | 659 | |
| chr20:64,062,561–64,063,881 | 168.0 kb | Distal (>10kb) Multiome | 991 | |
| chr20:64,079,311–64,080,472 | 184.8 kb | Distal (>10kb) Multiome | 688 | |
| chr20:64,083,392–64,084,408 | 188.6 kb | Distal (>10kb) Multiome | 591 | |
| chr20:64,101,897–64,102,924 | 207.2 kb | Distal (>10kb) Multiome | 457 | |
| chr20:64,160,199–64,160,889 | 265.4 kb | Distal (>10kb) Multiome | 55 |
Genomic view of the DNAJC5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.