HNF4A

hepatocyte nuclear factor 4 alpha | HNF4, NR2A1, MODY, MODY1, TCF14

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

Member of: DE-2 DE-2.21 Developmental clusters: GC7

Biological processes 65 terms

DNA binding (GO:0003677)DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)blood coagulation (GO:0007596)cell differentiation (GO:0030154)cholesterol homeostasis (GO:0042632)cholesterol homeostasis (GO:0042632)chromatin (GO:0000785)chromatin binding (GO:0003682)cytoplasm (GO:0005737)fatty acid binding (GO:0005504)glucose homeostasis (GO:0042593)glucose homeostasis (GO:0042593)intracellular receptor signaling pathway (GO:0030522)lipid homeostasis (GO:0055088)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of cell growth (GO:0030308)negative regulation of cell population proliferation (GO:0008285)nuclear receptor activity (GO:0004879)nuclear receptor activity (GO:0004879)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)phospholipid homeostasis (GO:0055091)phospholipid homeostasis (GO:0055091)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of ornithine catabolic process (GO:1903268)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)regulation of DNA-templated transcription (GO:0006355)regulation of circadian rhythm (GO:0042752)regulation of circadian rhythm (GO:0042752)regulation of growth hormone receptor signaling pathway (GO:0060398)regulation of insulin secretion (GO:0050796)regulation of insulin secretion (GO:0050796)regulation of lipid metabolic process (GO:0019216)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)response to glucose (GO:0009749)response to glucose (GO:0009749)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)signaling receptor binding (GO:0005102)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)triglyceride homeostasis (GO:0070328)triglyceride homeostasis (GO:0070328)xenobiotic metabolic process (GO:0006805)zinc ion binding (GO:0008270)

Expression (TPM)