Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for PIK3CA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIK3CA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIK3CA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:178,964,368–178,964,920 | 183.6 kb | Distal (>10kb) Multiome | 96 | |
| chr3:179,071,152–179,072,483 | 76.5 kb | Distal (>10kb) Multiome | 794 | |
| chr3:179,143,347–179,143,670 | 4.7 kb | Proximal (<10kb) | 23 | |
| chr3:179,147,033–179,149,466 | 126 bp | At TSS Multiome | 953 | |
| chr3:179,152,450–179,152,876 | 4.1 kb | Proximal (<10kb) | 14 | |
| chr3:179,260,956–179,261,810 | 113.1 kb | Distal (>10kb) Multiome | 616 | |
| chr3:179,322,380–179,323,876 | 174.6 kb | Distal (>10kb) Multiome | 958 | |
| chr3:179,346,338–179,348,224 | 199.3 kb | Distal (>10kb) Multiome | 843 |
Genomic view of the PIK3CA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.