This module contains 11 genes including REST, STK38, MIA3, UBE2K, and CLPX, with top enriched terms related to protein ubiquitination, proteasomal degradation, and cellular stress responses. Knockdown of REST activates this module, while knockdown of SOX2 and NANOG repress it. These results suggest that REST normally suppresses genes involved in protein quality control pathways during early endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.