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DE-2.31

Submodule 12 genes

Apoptosis and stress response signaling

This module contains 12 genes including MAVS, GAK, PPP1R13B, MAPK8IP3, and MYO18A, with enrichment in apoptosis, stress response, and innate immunity pathways. Knockdown of SOX17 activates this module, while knockdown of EOMESODERMIN and FOXA2 represses it.

Key terms: positive regulation of immune effector process regulation of myeloid leukocyte mediated immunity regulation of immune effector process Golgi organization Notable genes: MAVS GAK PPP1R13B MAPK8IP3 MYO18A DOCK6 WDR19 CERS5

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (12)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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