DE-2

DE-2.7

Submodule 23 genes

G-protein signaling and RNA binding regulation

This module contains 23 genes including GNAQ, IGF2R, MRTFA, and CELF1, enriched for G-protein coupled receptor signaling, RNA binding, and mRNA processing. Knockdown of SOX11 activates this module. No repressing transcription factors were identified.

Notable genes: GNAQ IGF2R MRTFA CELF1 ATXN7 SETX MYH10 FRS2 Top TFs: SOX11

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding
Perturbation only
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).


Module Genes (23)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z