This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for NR2C2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NR2C2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NR2C2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:14,651,173–14,652,219 | 296.0 kb | Distal (>10kb) Multiome | 942 | |
| chr3:14,810,059–14,811,386 | 137.0 kb | Distal (>10kb) Multiome | 162 | |
| chr3:14,847,690–14,848,492 | 99.4 kb | Distal (>10kb) Multiome | 317 | |
| chr3:14,947,039–14,949,016 | 888 bp | At TSS Multiome | 992 | |
| chr3:15,064,860–15,065,480 | 117.7 kb | Distal (>10kb) Multiome | 832 | |
| chr3:15,098,771–15,099,764 | 151.6 kb | Distal (>10kb) Multiome | 1059 | |
| chr3:15,118,530–15,119,129 | 171.3 kb | Distal (>10kb) Multiome | 281 |
Genomic view of the NR2C2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.