This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for YES1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YES1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YES1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:516,064–516,762 | 296.2 kb | Distal (>10kb) Multiome | 96 | |
| chr18:596,942–597,511 | 215.5 kb | Distal (>10kb) Multiome | 522 | |
| chr18:657,152–658,975 | 154.2 kb | Distal (>10kb) Multiome | 968 | |
| chr18:685,991–687,114 | 126.0 kb | Distal (>10kb) Multiome HiCAR | 127 | |
| chr18:712,215–713,458 | 99.8 kb | Distal (>10kb) Multiome | 797 | |
| chr18:811,520–813,366 | 82 bp | At TSS Multiome | 893 | |
| chr18:906,154–908,403 | 94.2 kb | Distal (>10kb) Multiome | 273 |
Genomic view of the YES1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.