This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for CCDC88A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC88A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC88A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:55,133,866–55,134,461 | 285.8 kb | Distal (>10kb) Multiome | 417 | |
| chr2:55,223,149–55,223,979 | 196.2 kb | Distal (>10kb) Multiome | 386 | |
| chr2:55,231,636–55,233,143 | 187.5 kb | Distal (>10kb) Multiome | 993 | |
| chr2:55,268,856–55,269,481 | 150.6 kb | Distal (>10kb) Multiome | 1083 | |
| chr2:55,279,327–55,280,579 | 140.1 kb | Distal (>10kb) Multiome | 219 | |
| chr2:55,281,727–55,282,873 | 137.6 kb | Distal (>10kb) Multiome | 943 | |
| chr2:55,418,822–55,420,474 | 98 bp | At TSS Multiome | 1181 | |
| chr2:55,518,709–55,520,527 | 99.7 kb | Distal (>10kb) Multiome | 882 | |
| chr2:55,616,515–55,618,979 | 197.9 kb | Distal (>10kb) Multiome | 1070 | |
| chr2:55,655,290–55,655,957 | 235.6 kb | Distal (>10kb) Multiome | 99 | |
| chr2:55,693,163–55,694,032 | 274.0 kb | Distal (>10kb) Multiome | 875 |
Genomic view of the CCDC88A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.