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DE-2.23

Submodule 14 genes

DNA repair and nuclear transport processes

This module contains 14 genes including TOP1, MIR17HG, CUL3, YES1, and TNPO1, with enrichment in DNA repair, nuclear transport, and ubiquitin-mediated proteolysis. Knockdown of SOX17, EOMES, and GATA4 activates this module. Knockdown of FOXA2, GSC, and NANOG represses this module.

Key terms: protein K48-linked ubiquitination protein polyubiquitination negative regulation of cilium assembly Notable genes: TOP1 CUL3 MIR17HG YES1 TNPO1 KPNA4 RYBP STK24

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (14)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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