This module contains 10 genes including MAP3K7, SPOP, GNAI1, MARCHF5, and USP33, with enrichment in protein ubiquitination, proteasomal degradation, and intracellular signaling pathways. Knockdown of SOX17 activates this module, while knockdown of NANOG and OCT4 repress it. These results suggest the module represents a regulatory axis where pluripotency factors normally suppress protein degradation pathways during stem cell maintenance.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.