This gene encodes an atypical inhibitor of the small G protein RhoA. Inhibition of RhoA activity by the encoded protein mediates myoblast fusion and polarization of T cells and neutrophils. The encoded protein is a component of hair cell stereocilia that is essential for hearing. A splice site mutation in this gene results in hearing loss in human patients. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for RIPOR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIPOR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIPOR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:24,645,624–24,646,552 | 289.8 kb | Distal (>10kb) Multiome | 641 | |
| chr6:24,666,308–24,667,466 | 269.0 kb | Distal (>10kb) Multiome | 1037 | |
| chr6:24,719,378–24,722,053 | 214.7 kb | Distal (>10kb) Multiome | 1238 | |
| chr6:24,774,256–24,775,895 | 160.8 kb | Distal (>10kb) Multiome | 1073 | |
| chr6:24,876,685–24,877,463 | at TSS | At TSS | 131 | |
| chr6:24,909,909–24,910,200 | 869 bp | At TSS | 77 | |
| chr6:24,910,313–24,911,578 | 24.9 kb | Distal (>10kb) Multiome | 372 | |
| chr6:24,918,781–24,919,332 | 7.7 kb | Proximal (<10kb) | 99 | |
| chr6:24,933,940–24,934,132 | 1.8 kb | Proximal (<10kb) | 132 | |
| chr6:24,935,428–24,935,754 | 205 bp | At TSS | 58 | |
| chr6:24,935,855–24,936,125 | at TSS | At TSS | 166 | |
| chr6:24,943,635–24,944,280 | 7.7 kb | Proximal (<10kb) | 15 | |
| chr6:24,980,508–24,981,759 | 45.2 kb | Distal (>10kb) Multiome HiCAR | 163 |
Genomic view of the RIPOR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.