This 16-gene module includes STIM1, PDE5A, WWP2, DEPDC5, and SLC12A6, with top enriched terms related to calcium ion binding, phosphodiesterase activity, and ion transport. Knockdown of SOX17 activates this module, while knockdown of FOXA2, EOMES, and GSC repress it. These regulatory patterns suggest the module is suppressed during normal endoderm specification and becomes active when key endoderm-driving transcription factors are removed.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.