Enables calcium ion binding activity and protein homodimerization activity. Involved in B cell differentiation. Located in endoplasmic reticulum and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TPD52. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPD52 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPD52, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:79,890,536–79,892,143 | 280.6 kb | Distal (>10kb) Multiome | 606 | |
| chr8:80,029,587–80,030,640 | 141.4 kb | Distal (>10kb) Multiome | 989 | |
| chr8:80,170,981–80,171,950 | 116 bp | At TSS Multiome | 771 | |
| chr8:80,211,280–80,212,758 | 40.3 kb | Distal (>10kb) Multiome | 216 | |
| chr8:80,231,585–80,232,350 | 60.5 kb | Distal (>10kb) Multiome | 124 | |
| chr8:80,240,457–80,241,089 | 69.2 kb | Distal (>10kb) Multiome | 564 | |
| chr8:80,279,352–80,280,425 | 108.2 kb | Distal (>10kb) Multiome | 186 |
Genomic view of the TPD52 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.