Transcription factors with Perturb-seq knockdown data for LINC00632. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00632 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00632, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:140,438,834–140,440,080 | 270.1 kb | Distal (>10kb) Multiome | 254 | |
| chrX:140,507,747–140,508,370 | 201.6 kb | Distal (>10kb) Multiome | 176 | |
| chrX:140,672,937–140,673,673 | 36.4 kb | Distal (>10kb) Multiome | 210 | |
| chrX:140,712,901–140,713,363 | 3.1 kb | Proximal (<10kb) | 170 | |
| chrX:140,758,701–140,758,930 | 5.6 kb | Proximal (<10kb) | 4 | |
| chrX:140,762,170–140,762,409 | 2.2 kb | Proximal (<10kb) | 102 | |
| chrX:140,764,254–140,764,990 | at TSS | At TSS | 191 | |
| chrX:140,765,098–140,765,413 | 526 bp | At TSS | 53 | |
| chrX:140,766,102–140,766,303 | 1.5 kb | Proximal (<10kb) | 63 | |
| chrX:140,770,132–140,770,524 | 5.6 kb | Proximal (<10kb) | 6 |
Genomic view of the LINC00632 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.