The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DLGAP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLGAP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLGAP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:36,010,700–36,011,324 | 295.4 kb | Distal (>10kb) Multiome | 70 | |
| chr20:36,050,468–36,051,316 | 255.4 kb | Distal (>10kb) Multiome | 1033 | |
| chr20:36,064,282–36,065,619 | 241.5 kb | Distal (>10kb) Multiome | 798 | |
| chr20:36,092,411–36,092,942 | 213.8 kb | Distal (>10kb) Multiome | 320 | |
| chr20:36,154,232–36,155,251 | 151.7 kb | Distal (>10kb) Multiome | 526 | |
| chr20:36,259,130–36,259,999 | 46.8 kb | Distal (>10kb) Multiome HiCAR | 159 | |
| chr20:36,306,218–36,306,746 | 1 bp | At TSS Multiome | 148 | |
| chr20:36,399,522–36,399,982 | 93.5 kb | Distal (>10kb) Multiome | 345 | |
| chr20:36,435,969–36,436,607 | 130.0 kb | Distal (>10kb) Multiome | 268 | |
| chr20:36,460,578–36,462,746 | 155.0 kb | Distal (>10kb) Multiome | 955 | |
| chr20:36,465,138–36,465,716 | 3.6 kb | Proximal (<10kb) | 338 | |
| chr20:36,540,956–36,541,869 | 235.1 kb | Distal (>10kb) Multiome | 305 | |
| chr20:36,571,701–36,572,151 | 265.5 kb | Distal (>10kb) Multiome | 361 | |
| chr20:36,572,535–36,575,795 | 267.1 kb | Distal (>10kb) Multiome | 1083 | |
| chr20:36,585,521–36,586,119 | 279.4 kb | Distal (>10kb) Multiome | 314 | |
| chr20:36,604,973–36,606,237 | 299.3 kb | Distal (>10kb) Multiome | 1049 | |
| chr20:36,676,551–36,678,157 | 371.0 kb | Distal (>10kb) Multiome | 370 | |
| chr20:36,745,462–36,746,528 | 439.8 kb | Distal (>10kb) Multiome | 739 |
Genomic view of the DLGAP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.