This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for SLCO2A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLCO2A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLCO2A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:133,805,616–133,806,520 | 224.1 kb | Distal (>10kb) Multiome | 710 | |
| chr3:133,894,751–133,896,433 | 134.1 kb | Distal (>10kb) Multiome | 424 | |
| chr3:133,927,020–133,928,082 | 102.3 kb | Distal (>10kb) Multiome | 363 | |
| chr3:133,988,622–133,989,245 | 41.0 kb | Distal (>10kb) Multiome | 246 | |
| chr3:134,019,494–134,020,043 | 9.9 kb | Proximal (<10kb) | 15 | |
| chr3:134,028,965–134,030,691 | 147 bp | At TSS Multiome | 495 | |
| chr3:134,039,200–134,039,795 | 9.3 kb | Proximal (<10kb) | 222 | |
| chr3:134,250,095–134,251,199 | 220.9 kb | Distal (>10kb) Multiome | 719 | |
| chr3:134,308,427–134,308,921 | 278.8 kb | Distal (>10kb) Multiome | 478 | |
| chr3:134,312,827–134,313,997 | 283.5 kb | Distal (>10kb) Multiome | 368 |
Genomic view of the SLCO2A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.