This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Transcription factors with Perturb-seq knockdown data for MARK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MARK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MARK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:63,613,506–63,614,656 | 224.7 kb | Distal (>10kb) Multiome | 502 | |
| chr11:63,670,776–63,672,118 | 167.4 kb | Distal (>10kb) Multiome | 715 | |
| chr11:63,680,920–63,682,270 | 157.6 kb | Distal (>10kb) Multiome | 869 | |
| chr11:63,761,764–63,765,204 | 75.0 kb | Distal (>10kb) Multiome | 463 | |
| chr11:63,767,471–63,769,982 | 71.5 kb | Distal (>10kb) Multiome | 627 | |
| chr11:63,813,022–63,814,238 | 25.7 kb | Distal (>10kb) Multiome | 704 | |
| chr11:63,837,125–63,837,513 | 1.4 kb | Proximal (<10kb) | 249 | |
| chr11:63,838,214–63,839,799 | 166 bp | At TSS Multiome | 687 | |
| chr11:63,887,484–63,887,927 | 618 bp | At TSS | 36 | |
| chr11:63,888,171–63,888,861 | 49.4 kb | Distal (>10kb) Multiome HiCAR | 565 | |
| chr11:63,909,610–63,910,221 | 70.9 kb | Distal (>10kb) Multiome HiCAR | 113 | |
| chr11:63,916,069–63,921,372 | 80.4 kb | Distal (>10kb) Multiome HiCAR | 929 | |
| chr11:63,938,087–63,939,846 | 99.7 kb | Distal (>10kb) Multiome | 852 | |
| chr11:63,974,156–63,975,123 | 135.4 kb | Distal (>10kb) Multiome | 918 | |
| chr11:63,986,198–63,987,213 | 147.4 kb | Distal (>10kb) Multiome | 895 | |
| chr11:63,998,533–64,001,109 | 160.3 kb | Distal (>10kb) Multiome | 414 | |
| chr11:64,028,126–64,028,898 | 189.5 kb | Distal (>10kb) Multiome | 168 |
Genomic view of the MARK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.