This gene belongs to the IQ motif-containing family of proteins. The IQ motif serves as a binding site for different EF-hand proteins such as calmodulin. This gene was identified as a potential candidate gene for obsessive-compulsive disorder in a genome-wide association study. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Transcription factors with Perturb-seq knockdown data for IQCK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IQCK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IQCK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:19,487,848–19,488,641 | 230.1 kb | Distal (>10kb) Multiome | 340 | |
| chr16:19,521,532–19,522,649 | 196.2 kb | Distal (>10kb) Multiome | 825 | |
| chr16:19,523,702–19,524,351 | 194.4 kb | Distal (>10kb) Multiome | 765 | |
| chr16:19,555,060–19,556,522 | 162.8 kb | Distal (>10kb) Multiome | 1001 | |
| chr16:19,717,856–19,718,929 | 35 bp | At TSS Multiome | 935 | |
| chr16:19,722,929–19,723,622 | 4.9 kb | Proximal (<10kb) Multiome | 66 | |
| chr16:19,853,872–19,854,881 | 136.1 kb | Distal (>10kb) Multiome | 59 | |
| chr16:19,884,718–19,885,614 | 166.7 kb | Distal (>10kb) Multiome HiCAR | 352 |
Genomic view of the IQCK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.