This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
Transcription factors with Perturb-seq knockdown data for NCOR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCOR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCOR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:124,130,469–124,131,898 | 436.7 kb | Distal (>10kb) Multiome | 640 | |
| chr12:124,294,909–124,295,848 | 272.5 kb | Distal (>10kb) Multiome | 154 | |
| chr12:124,316,919–124,317,729 | 250.3 kb | Distal (>10kb) Multiome | 42 | |
| chr12:124,318,202–124,319,225 | 248.9 kb | Distal (>10kb) Multiome | 147 | |
| chr12:124,320,878–124,321,486 | 246.4 kb | Distal (>10kb) Multiome HiCAR | 287 | |
| chr12:124,512,875–124,513,551 | 54.3 kb | Distal (>10kb) Multiome HiCAR | 391 | |
| chr12:124,565,079–124,565,470 | 2.0 kb | Proximal (<10kb) | 126 | |
| chr12:124,566,229–124,568,213 | 1.1 kb | Proximal (<10kb) Multiome | 705 | |
| chr12:124,568,509–124,568,946 | 1.0 kb | Proximal (<10kb) | 356 | |
| chr12:124,605,711–124,606,156 | 38.3 kb | Distal (>10kb) Multiome | 139 | |
| chr12:124,734,326–124,734,809 | 167.0 kb | Distal (>10kb) Multiome HiCAR | 298 | |
| chr12:124,807,344–124,807,806 | 240.1 kb | Distal (>10kb) Multiome | 114 | |
| chr12:124,863,018–124,864,505 | 296.3 kb | Distal (>10kb) Multiome | 853 |
Genomic view of the NCOR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.