Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within several processes, including mitochondrion organization; photoreceptor cell development; and spermatogenesis. Predicted to be located in mitochondrial membrane and nuclear membrane. Predicted to be active in nucleus. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TUG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TUG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TUG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:30,694,739–30,695,381 | 274.5 kb | Distal (>10kb) Multiome | 278 | |
| chr22:30,802,592–30,803,363 | 166.3 kb | Distal (>10kb) Multiome | 898 | |
| chr22:30,968,406–30,969,906 | 121 bp | At TSS Multiome | 897 | |
| chr22:31,080,687–31,081,783 | 111.9 kb | Distal (>10kb) Multiome HiCAR | 636 | |
| chr22:31,084,596–31,085,743 | 115.9 kb | Distal (>10kb) Multiome HiCAR | 448 | |
| chr22:31,098,574–31,099,237 | 129.6 kb | Distal (>10kb) Multiome | 150 | |
| chr22:31,104,824–31,105,447 | 135.8 kb | Distal (>10kb) Multiome | 187 | |
| chr22:31,107,269–31,107,915 | 138.4 kb | Distal (>10kb) Multiome | 627 | |
| chr22:31,127,262–31,127,766 | 158.3 kb | Distal (>10kb) Multiome | 74 | |
| chr22:31,140,179–31,140,721 | 171.3 kb | Distal (>10kb) Multiome | 244 | |
| chr22:31,160,052–31,160,698 | 191.0 kb | Distal (>10kb) Multiome | 709 | |
| chr22:31,211,835–31,212,727 | 243.0 kb | Distal (>10kb) Multiome | 769 |
Genomic view of the TUG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.