The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for SSH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SSH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SSH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:108,560,717–108,561,713 | 296.4 kb | Distal (>10kb) Multiome | 703 | |
| chr12:108,561,872–108,563,300 | 295.0 kb | Distal (>10kb) Multiome | 772 | |
| chr12:108,691,447–108,691,929 | 165.9 kb | Distal (>10kb) Multiome | 745 | |
| chr12:108,730,199–108,732,667 | 125.7 kb | Distal (>10kb) Multiome | 993 | |
| chr12:108,802,154–108,802,651 | 55.3 kb | Distal (>10kb) Multiome | 135 | |
| chr12:108,855,721–108,856,362 | 1.2 kb | Proximal (<10kb) | 366 | |
| chr12:108,856,753–108,858,260 | 120 bp | At TSS Multiome | 698 | |
| chr12:109,052,237–109,053,072 | 195.0 kb | Distal (>10kb) Multiome | 965 | |
| chr12:109,069,700–109,070,229 | 212.4 kb | Distal (>10kb) Multiome | 118 | |
| chr12:109,093,224–109,093,868 | 236.0 kb | Distal (>10kb) Multiome | 998 | |
| chr12:109,097,190–109,098,740 | 240.5 kb | Distal (>10kb) Multiome | 758 | |
| chr12:109,110,997–109,111,481 | 253.6 kb | Distal (>10kb) Multiome | 593 | |
| chr12:109,154,096–109,155,355 | 297.3 kb | Distal (>10kb) Multiome | 595 |
Genomic view of the SSH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.