This 13-gene module includes ROCK1, CREM, HIPK1, FNTB, and KPNA5, with enriched terms related to Rho protein signal transduction, protein phosphorylation, and intracellular protein transport. Knockdown of SOX17, EOMES, and FOXA2 activates this module. Knockdown of NANOG represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.