The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020]
Transcription factors with Perturb-seq knockdown data for MTOR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTOR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTOR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:11,011,823–11,013,364 | 250.1 kb | Distal (>10kb) Multiome | 974 | |
| chr1:11,052,805–11,053,698 | 209.2 kb | Distal (>10kb) Multiome | 314 | |
| chr1:11,059,469–11,060,508 | 202.4 kb | Distal (>10kb) Multiome | 659 | |
| chr1:11,099,300–11,100,191 | 162.8 kb | Distal (>10kb) Multiome | 798 | |
| chr1:11,262,158–11,262,957 | 161 bp | At TSS Multiome | 805 | |
| chr1:11,272,615–11,274,143 | 10.6 kb | Distal (>10kb) Multiome | 912 | |
| chr1:11,311,832–11,312,672 | 49.8 kb | Distal (>10kb) Multiome | 49 | |
| chr1:11,478,503–11,480,383 | 216.5 kb | Distal (>10kb) Multiome | 732 |
Genomic view of the MTOR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.