This 20-gene module includes CTNNB1, ACVR1, DIAPH1, CCDC88A, and SMURF2, with enrichment in Wnt signaling pathway, cytoskeletal organization, and protein ubiquitination. Knockdown of SOX17, EOMES, and FOXA2 activates this module. Knockdown of NANOG represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.