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DE-2.28

Submodule 13 genes

Calcium signaling and cell death regulation

This module contains 13 genes including TPD52, ITPR3, and DAPK2, with top enrichment in calcium signaling, apoptosis, and cell death processes. Knockdown of SOX17 activates this module, while knockdown of NANOG and OCT4 represses it.

Key terms: regulation of eosinophil migration D-glucuronate catabolic process glucuronate metabolic process D-glucuronate catabolic process to D-xylulose 5-phosphate Notable genes: TPD52 ITPR3 DAPK2 L2HGDH SYNJ2 ATG4C SPATA13 MAP3K21

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (13)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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High z
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