Enables (S)-citramalyl-CoA lyase activity; magnesium ion binding activity; and malate synthase activity. Involved in protein homotrimerization and regulation of cobalamin metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CLYBL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLYBL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLYBL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:99,307,801–99,308,401 | 298.6 kb | Distal (>10kb) Multiome | 300 | |
| chr13:99,498,126–99,499,495 | 108.0 kb | Distal (>10kb) Multiome | 771 | |
| chr13:99,500,804–99,502,197 | 105.3 kb | Distal (>10kb) Multiome | 847 | |
| chr13:99,600,367–99,600,779 | 5.9 kb | Proximal (<10kb) | 114 | |
| chr13:99,605,931–99,607,157 | 62 bp | At TSS Multiome | 845 | |
| chr13:99,614,577–99,614,812 | 7.9 kb | Proximal (<10kb) | 205 | |
| chr13:99,657,854–99,658,963 | 51.8 kb | Distal (>10kb) Multiome | 252 | |
| chr13:99,686,744–99,688,098 | 80.5 kb | Distal (>10kb) Multiome | 332 | |
| chr13:99,818,120–99,818,590 | 211.6 kb | Distal (>10kb) Multiome | 93 | |
| chr13:99,955,497–99,958,187 | 351.0 kb | Distal (>10kb) Multiome HiCAR | 501 | |
| chr13:99,970,037–99,972,702 | 364.5 kb | Distal (>10kb) Multiome HiCAR | 629 | |
| chr13:99,978,424–99,982,746 | 372.5 kb | Distal (>10kb) Multiome HiCAR | 812 | |
| chr13:100,510,174–100,511,130 | 903.8 kb | Distal (>10kb) Multiome HiCAR | 264 | |
| chr13:100,588,327–100,589,133 | 982.1 kb | Distal (>10kb) Multiome HiCAR | 783 | |
| chr13:100,591,344–100,592,134 | 985.1 kb | Distal (>10kb) Multiome HiCAR | 51 | |
| chr13:100,673,359–100,675,821 | 1068.3 kb | Distal (>10kb) Multiome HiCAR | 760 |
Genomic view of the CLYBL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.