This 16-gene module includes LYPLAL1, DMGDH, RNF13, and TTC8, with top enriched terms indicating roles in lipid metabolism, protein ubiquitination, and proteasomal degradation. Knockdown of SOX17 activates this module, while knockdown of EOMESODERMIN represses it. The module's enrichment suggests coordinated regulation of lipid catabolism and protein quality control during endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.