This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for RBMS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBMS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBMS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:160,202,276–160,203,083 | 291.1 kb | Distal (>10kb) Multiome | 73 | |
| chr2:160,208,176–160,209,127 | 285.2 kb | Distal (>10kb) Multiome | 355 | |
| chr2:160,269,466–160,271,913 | 223.6 kb | Distal (>10kb) Multiome | 937 | |
| chr2:160,406,892–160,408,501 | 86.0 kb | Distal (>10kb) Multiome | 603 | |
| chr2:160,478,687–160,479,687 | 14.9 kb | Distal (>10kb) Multiome | 142 | |
| chr2:160,482,730–160,482,992 | 10.0 kb | Proximal (<10kb) | 95 | |
| chr2:160,484,997–160,485,383 | 7.6 kb | Proximal (<10kb) | 29 | |
| chr2:160,492,645–160,494,676 | 117 bp | At TSS Multiome | 884 | |
| chr2:160,651,366–160,652,689 | 158.2 kb | Distal (>10kb) Multiome | 174 |
Genomic view of the RBMS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.