Enables SMAD binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent protein catabolic process. Located in nuclear speck. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMURF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMURF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMURF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:64,470,609–64,471,086 | 191.4 kb | Distal (>10kb) Multiome | 39 | |
| chr17:64,496,498–64,497,782 | 165.1 kb | Distal (>10kb) Multiome | 1074 | |
| chr17:64,504,990–64,507,698 | 156.9 kb | Distal (>10kb) Multiome | 1232 | |
| chr17:64,661,214–64,662,931 | 21 bp | At TSS Multiome | 700 | |
| chr17:64,773,965–64,774,847 | 112.1 kb | Distal (>10kb) Multiome | 481 | |
| chr17:64,776,631–64,777,384 | 114.7 kb | Distal (>10kb) Multiome | 616 | |
| chr17:64,778,215–64,779,097 | 116.4 kb | Distal (>10kb) Multiome | 185 | |
| chr17:64,779,868–64,781,331 | 118.1 kb | Distal (>10kb) Multiome | 287 | |
| chr17:64,836,863–64,837,361 | 174.8 kb | Distal (>10kb) Multiome | 286 | |
| chr17:64,918,788–64,920,342 | 257.2 kb | Distal (>10kb) Multiome | 704 |
Genomic view of the SMURF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.