This module contains 44 genes including CCM2, PLCG1, STK4, CRY1, and VAPB, enriched for calcium signaling, phospholipase C activity, and second messenger signaling pathways. Knockdown of SOX17, EOMESODERMIN, and FOXA2 activates this module. Knockdown of GATA4, GATA6, and NODAL represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.