This 30-gene module contains RB1, LRP5, SMO, and SKI, with top enriched terms including Hedgehog signaling pathway, Wnt signaling pathway, and transcriptional regulation. Knockdown of SOX17, EOMES, and FOXA2 activates this module. Knockdown of GATA6, GATA4, and CDX2 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.