This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for IRS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IRS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IRS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:226,030,242–226,031,857 | 768.5 kb | Distal (>10kb) Multiome HiCAR | 784 | |
| chr2:226,649,671–226,650,681 | 149.5 kb | Distal (>10kb) Multiome HiCAR | 758 | |
| chr2:226,720,273–226,721,822 | 78.7 kb | Distal (>10kb) Multiome | 136 | |
| chr2:226,790,932–226,792,958 | 8.1 kb | Proximal (<10kb) Multiome | 707 | |
| chr2:226,796,779–226,797,154 | 2.7 kb | Proximal (<10kb) | 134 | |
| chr2:226,797,838–226,801,976 | 1.5 kb | Proximal (<10kb) Multiome | 1020 | |
| chr2:226,802,608–226,802,787 | 2.8 kb | Proximal (<10kb) | 215 | |
| chr2:226,835,365–226,836,725 | 36.2 kb | Distal (>10kb) Multiome | 964 | |
| chr2:226,874,251–226,875,681 | 75.0 kb | Distal (>10kb) Multiome | 292 |
Genomic view of the IRS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.