POR

cytochrome p450 oxidoreductase | CYPOR, FLJ26468

This gene encodes an endoplasmic reticulum membrane oxidoreductase that is essential for multiple metabolic processes, including reactions catalyzed by cytochrome P450 proteins for metabolism of steroid hormones, drugs and xenobiotics. The encoded protein has a flavin adenine dinucleotide (FAD)-binding domain and a flavodoxin-like domain which bind two cofactors, FAD and FMN, that allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene cause a complex set of disorders, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome, that resemble those caused by defects in steroid metabolizing enzymes such as aromatase, 21-hydroxylase, and 17 alpha-hydroxylase. [provided by RefSeq, Aug 2020]

Member of: DE-2 DE-2.15

Biological processes 47 terms

FMN binding (GO:0010181)FMN binding (GO:0010181)NADP binding (GO:0050661)NADPH-hemoprotein reductase activity (GO:0003958)NADPH-hemoprotein reductase activity (GO:0003958)NADPH-hemoprotein reductase activity (GO:0003958)NADPH-hemoprotein reductase activity (GO:0003958)P450-containing electron transport chain (GO:0140647)carnitine metabolic process (GO:0009437)cellular response to follicle-stimulating hormone stimulus (GO:0071372)cellular response to gonadotropin stimulus (GO:0071371)cellular response to peptide hormone stimulus (GO:0071375)cytochrome-b5 reductase activity, acting on NAD(P)H (GO:0004128)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)demethylation (GO:0070988)electron transfer activity (GO:0009055)electron transport chain (GO:0022900)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)enzyme activator activity (GO:0008047)enzyme binding (GO:0019899)fatty acid oxidation (GO:0019395)flavin adenine dinucleotide binding (GO:0050660)flavin adenine dinucleotide binding (GO:0050660)hydrolase activity (GO:0016787)intracellular membrane-bounded organelle (GO:0043231)iron-cytochrome-c reductase activity (GO:0047726)membrane (GO:0016020)negative regulation of apoptotic process (GO:0043066)nitrate catabolic process (GO:0043602)nitric oxide biosynthetic process (GO:0006809)nitric oxide catabolic process (GO:0046210)nitric oxide dioxygenase NAD(P)H activity (GO:0008941)nucleoplasm (GO:0005654)organofluorine metabolic process (GO:0090346)oxidoreductase activity (GO:0016491)positive regulation of chondrocyte differentiation (GO:0032332)positive regulation of growth plate cartilage chondrocyte proliferation (GO:0061913)positive regulation of smoothened signaling pathway (GO:0045880)positive regulation of steroid hormone biosynthetic process (GO:0090031)protein binding (GO:0005515)response to dexamethasone (GO:0071548)response to hormone (GO:0009725)response to nutrient (GO:0007584)response to xenobiotic stimulus (GO:0009410)

Expression (TPM)

TFs regulating POR 0 TFs

Transcription factors with Perturb-seq knockdown data for POR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to POR

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:75,638,467–75,640,092	275.5 kb	Distal (>10kb) Multiome	654
chr7:75,738,406–75,739,915	175.9 kb	Distal (>10kb) Multiome	795
chr7:75,778,655–75,779,512	136.0 kb	Distal (>10kb) Multiome	54
chr7:75,780,667–75,781,151	134.3 kb	Distal (>10kb) Multiome	106
chr7:75,788,149–75,788,821	126.7 kb	Distal (>10kb) Multiome	95
chr7:75,878,577–75,879,573	36.2 kb	Distal (>10kb) Multiome	883
chr7:75,914,282–75,915,911	103 bp	At TSS Multiome	1021
chr7:75,993,473–75,995,401	79.5 kb	Distal (>10kb) Multiome	873
chr7:76,047,582–76,048,952	132.9 kb	Distal (>10kb) Multiome	920
chr7:76,073,173–76,073,663	158.3 kb	Distal (>10kb) Multiome	100
chr7:76,163,449–76,164,544	248.8 kb	Distal (>10kb) Multiome	132
chr7:76,166,338–76,167,166	251.5 kb	Distal (>10kb) Multiome	644
chr7:76,177,965–76,178,641	263.2 kb	Distal (>10kb) Multiome	670
chr7:76,201,356–76,202,307	286.7 kb	Distal (>10kb) Multiome	937

Genome Browser

Genomic view of the POR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.