ZDHHC20

zDHHC palmitoyltransferase 20 | DHHC20, FLJ25952

Enables protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Involved in peptidyl-L-cysteine S-palmitoylation and positive regulation by host of viral process. Located in Golgi membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2 DE-2.34

Biological processes 32 terms

DNA damage response (GO:0006974)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)cytoplasmic vesicle membrane (GO:0030659)cytoplasmic vesicle membrane (GO:0030659)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)host-mediated activation of viral process (GO:0044794)membrane (GO:0016020)nucleus (GO:0005634)palmitoyltransferase activity (GO:0016409)palmitoyltransferase activity (GO:0016409)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of skeletal muscle tissue regeneration (GO:0043415)positive regulation of vesicle fusion (GO:0031340)protein binding (GO:0005515)protein maturation (GO:0051604)protein targeting to membrane (GO:0006612)protein-cysteine S-myristoyltransferase activity (GO:0019705)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-stearoyltransferase activity (GO:0140439)synaptic vesicle maturation (GO:0016188)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating ZDHHC20 0 TFs

Transcription factors with Perturb-seq knockdown data for ZDHHC20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZDHHC20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZDHHC20

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZDHHC20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr13:21,176,109–21,177,241	282.7 kb	Distal (>10kb) Multiome	933
chr13:21,297,800–21,298,863	161.1 kb	Distal (>10kb) Multiome	776
chr13:21,326,200–21,327,030	132.7 kb	Distal (>10kb) Multiome	179
chr13:21,410,303–21,410,800	48.7 kb	Distal (>10kb) Multiome	76
chr13:21,458,471–21,459,892	105 bp	At TSS Multiome	682
chr13:21,465,525–21,466,277	6.2 kb	Proximal (<10kb)	229
chr13:21,466,580–21,466,797	7.3 kb	Proximal (<10kb)	13
chr13:21,603,478–21,604,537	144.7 kb	Distal (>10kb) Multiome	918
chr13:21,669,106–21,671,240	211.7 kb	Distal (>10kb) Multiome	657
chr13:21,673,391–21,674,552	214.6 kb	Distal (>10kb) Multiome	365

Genome Browser

Genomic view of the ZDHHC20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.