This 11-gene module includes TNKS2, FOXK1, RAB6A, ATG14, and MORC3, with enrichment in autophagy, vesicular transport, and protein trafficking pathways. Knockdown of SOX17 activates this module, while knockdown of EOMESODERMIN, GATA4, and GATA6 repress it. The module suggests coordinated regulation of cellular degradation and transport processes during endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.