GNA12
G protein subunit alpha 12 | gep

Enables G protein activity; protein phosphatase 2A binding activity; and protein phosphatase activator activity. Involved in Rho-activating G protein-coupled receptor signaling pathway; regulation of TOR signaling; and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in lateral plasma membrane; neuron projection; and neuronal cell body. Is active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Member of: DE-2 DE-2.41
Biological processes 46 terms
D5 dopamine receptor binding (GO:0031752)D5 dopamine receptor binding (GO:0031752)G protein activity (GO:0003925)G protein activity (GO:0003925)G protein-coupled receptor binding (GO:0001664)G protein-coupled receptor signaling pathway (GO:0007186)G protein-coupled receptor signaling pathway (GO:0007186)G-protein beta/gamma-subunit complex binding (GO:0031683)G-protein beta/gamma-subunit complex binding (GO:0031683)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase activity (GO:0003924)Rho protein signal transduction (GO:0007266)Rho protein signal transduction (GO:0007266)Rho-activating G protein-coupled receptor signaling pathway (GO:0160221)Rho-activating G protein-coupled receptor signaling pathway (GO:0160221)adenylate cyclase-modulating G protein-coupled receptor signaling pathway (GO:0007188)blood coagulation (GO:0007596)brush border membrane (GO:0031526)brush border membrane (GO:0031526)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic side of plasma membrane (GO:0009898)cytoplasmic side of plasma membrane (GO:0009898)cytosol (GO:0005829)focal adhesion (GO:0005925)guanyl nucleotide binding (GO:0019001)heterotrimeric G-protein complex (GO:0005834)lateral plasma membrane (GO:0016328)lateral plasma membrane (GO:0016328)neuron projection (GO:0043005)neuronal cell body (GO:0043025)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)protein phosphatase 2A binding (GO:0051721)protein phosphatase activator activity (GO:0072542)regulation of TOR signaling (GO:0032006)regulation of TOR signaling (GO:0032006)regulation of blood pressure (GO:0008217)regulation of fibroblast migration (GO:0010762)regulation of fibroblast migration (GO:0010762)regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)response to xenobiotic stimulus (GO:0009410)signal transduction (GO:0007165)
Expression (TPM)
GNA12 — as a Regulated Gene

TFs regulating GNA12 0 TFs

Transcription factors with Perturb-seq knockdown data for GNA12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNA12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to GNA12

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNA12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr7:2,518,679–2,520,557 324.6 kb Distal (>10kb) Multiome 567
chr7:2,555,131–2,556,097 288.6 kb Distal (>10kb) Multiome 772
chr7:2,558,641–2,559,572 285.3 kb Distal (>10kb) Multiome 669
chr7:2,631,170–2,632,859 212.5 kb Distal (>10kb) Multiome 658
chr7:2,646,545–2,647,390 197.3 kb Distal (>10kb) Multiome 245
chr7:2,688,023–2,688,723 156.0 kb Distal (>10kb) Multiome 176
chr7:2,706,487–2,707,069 137.4 kb Distal (>10kb) Multiome 81
chr7:2,709,414–2,710,178 134.4 kb Distal (>10kb) Multiome 481
chr7:2,815,206–2,815,593 at TSS At TSS 99
chr7:2,821,232–2,821,746 22.8 kb Distal (>10kb) Multiome 210
chr7:2,824,789–2,825,101 9.5 kb Proximal (<10kb) 118
chr7:2,843,825–2,845,052 167 bp At TSS Multiome 635
chr7:4,700,808–4,701,595 1856.9 kb Distal (>10kb) Multiome HiCAR 166

Genome Browser

Genomic view of the GNA12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr7:2,508,679 – 4,711,595
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact