This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for LMAN2L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LMAN2L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LMAN2L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:96,507,900–96,508,563 | 231.9 kb | Distal (>10kb) Multiome | 466 | |
| chr2:96,509,253–96,509,998 | 230.4 kb | Distal (>10kb) Multiome | 525 | |
| chr2:96,531,989–96,532,491 | 207.8 kb | Distal (>10kb) Multiome | 500 | |
| chr2:96,536,180–96,538,128 | 203.3 kb | Distal (>10kb) Multiome | 684 | |
| chr2:96,538,413–96,539,012 | 201.3 kb | Distal (>10kb) Multiome | 371 | |
| chr2:96,554,285–96,554,861 | 185.5 kb | Distal (>10kb) Multiome | 435 | |
| chr2:96,637,810–96,638,901 | 101.7 kb | Distal (>10kb) Multiome | 1144 | |
| chr2:96,739,549–96,740,363 | 68 bp | At TSS Multiome | 708 | |
| chr2:96,760,354–96,761,531 | 20.8 kb | Distal (>10kb) Multiome | 776 | |
| chr2:96,762,598–96,764,653 | 23.0 kb | Distal (>10kb) Multiome | 406 | |
| chr2:96,815,434–96,817,859 | 76.2 kb | Distal (>10kb) Multiome | 926 | |
| chr2:96,857,099–96,859,416 | 118.1 kb | Distal (>10kb) Multiome | 1033 | |
| chr2:96,868,320–96,870,552 | 130.1 kb | Distal (>10kb) Multiome | 907 | |
| chr2:96,881,325–96,881,826 | 141.6 kb | Distal (>10kb) Multiome | 188 | |
| chr2:96,951,012–96,951,489 | 211.3 kb | Distal (>10kb) Multiome | 450 |
Genomic view of the LMAN2L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.