This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for INO80. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INO80 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INO80, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:40,843,756–40,844,502 | 272.1 kb | Distal (>10kb) Multiome | 364 | |
| chr15:40,873,588–40,874,396 | 242.3 kb | Distal (>10kb) Multiome | 556 | |
| chr15:40,893,927–40,894,547 | 222.0 kb | Distal (>10kb) Multiome | 741 | |
| chr15:40,906,419–40,906,902 | 209.7 kb | Distal (>10kb) Multiome | 630 | |
| chr15:40,941,651–40,942,174 | 174.3 kb | Distal (>10kb) Multiome | 643 | |
| chr15:40,952,899–40,953,683 | 163.0 kb | Distal (>10kb) Multiome | 618 | |
| chr15:41,115,645–41,116,753 | 140 bp | At TSS Multiome | 909 | |
| chr15:41,230,581–41,231,535 | 114.8 kb | Distal (>10kb) Multiome | 1063 | |
| chr15:41,283,739–41,284,308 | 167.7 kb | Distal (>10kb) Multiome | 798 | |
| chr15:41,332,102–41,333,206 | 216.4 kb | Distal (>10kb) Multiome | 883 |
Genomic view of the INO80 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.