This module contains 10 genes including ATP7B, DNAJC5, POM121, ZC3H7B, and BLTP3A, with enriched terms related to copper ion transport, metal homeostasis, and protein folding. Knockdown of SOX17 activates this module, while knockdown of EOMESODERMIN represses it. The module's activation upon SOX17 loss suggests a compensatory role in cellular metal handling during endoderm specification.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.