This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DNM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:127,916,386–127,917,505 | 286.3 kb | Distal (>10kb) Multiome | 474 | |
| chr9:127,926,756–127,928,574 | 275.8 kb | Distal (>10kb) Multiome | 411 | |
| chr9:127,930,321–127,931,068 | 272.6 kb | Distal (>10kb) Multiome | 537 | |
| chr9:127,937,578–127,938,244 | 265.5 kb | Distal (>10kb) Multiome | 674 | |
| chr9:127,955,445–127,955,915 | 247.8 kb | Distal (>10kb) Multiome | 540 | |
| chr9:127,980,172–127,981,966 | 222.3 kb | Distal (>10kb) Multiome | 691 | |
| chr9:128,033,544–128,034,106 | 169.5 kb | Distal (>10kb) Multiome | 69 | |
| chr9:128,034,940–128,035,527 | 168.0 kb | Distal (>10kb) Multiome | 480 | |
| chr9:128,066,577–128,068,774 | 136.0 kb | Distal (>10kb) Multiome | 874 | |
| chr9:128,097,872–128,098,910 | 105.0 kb | Distal (>10kb) Multiome | 712 | |
| chr9:128,117,658–128,118,328 | 85.5 kb | Distal (>10kb) Multiome | 640 | |
| chr9:128,127,314–128,128,793 | 75.1 kb | Distal (>10kb) Multiome | 899 | |
| chr9:128,159,371–128,160,928 | 43.2 kb | Distal (>10kb) Multiome | 824 | |
| chr9:128,191,300–128,192,050 | 11.7 kb | Distal (>10kb) Multiome | 865 | |
| chr9:128,203,004–128,204,704 | 1.0 kb | Proximal (<10kb) Multiome | 690 | |
| chr9:128,218,656–128,219,107 | 15.5 kb | Distal (>10kb) Multiome | 410 | |
| chr9:128,250,012–128,251,099 | 47.2 kb | Distal (>10kb) Multiome | 353 | |
| chr9:128,275,636–128,276,535 | 72.7 kb | Distal (>10kb) Multiome | 728 | |
| chr9:128,322,183–128,322,933 | 119.2 kb | Distal (>10kb) Multiome | 962 | |
| chr9:128,340,070–128,341,161 | 137.1 kb | Distal (>10kb) Multiome | 803 | |
| chr9:128,364,858–128,365,437 | 161.7 kb | Distal (>10kb) Multiome | 442 | |
| chr9:128,420,259–128,421,260 | 217.4 kb | Distal (>10kb) Multiome | 701 | |
| chr9:128,455,721–128,456,522 | 252.7 kb | Distal (>10kb) Multiome | 684 | |
| chr9:130,171,788–130,172,513 | 1968.9 kb | Distal (>10kb) Multiome HiCAR | 253 |
Genomic view of the DNM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.