SKI

SKI

SKI proto-oncogene

This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]

Member of: DE-2 DE-2.5

Biological processes 71 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor binding (GO:0140297)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)PML body (GO:0016605)PML body (GO:0016605)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)SMAD binding (GO:0046332)SMAD binding (GO:0046332)SMAD binding (GO:0046332)anterior/posterior axis specification (GO:0009948)bone morphogenesis (GO:0060349)camera-type eye development (GO:0043010)camera-type eye morphogenesis (GO:0048593)cardiac muscle cell proliferation (GO:0060038)cell motility (GO:0048870)centrosome (GO:0005813)cytoplasm (GO:0005737)cytoplasm (GO:0005737)embryonic limb morphogenesis (GO:0030326)face morphogenesis (GO:0060325)histone deacetylase inhibitor activity (GO:0046811)identical protein binding (GO:0042802)lens morphogenesis in camera-type eye (GO:0002089)muscle structure development (GO:0061061)myelination in peripheral nervous system (GO:0022011)myotube differentiation (GO:0014902)negative regulation of BMP signaling pathway (GO:0030514)negative regulation of BMP signaling pathway (GO:0030514)negative regulation of BMP signaling pathway (GO:0030514)negative regulation of SMAD protein signal transduction (GO:0060392)negative regulation of Schwann cell proliferation (GO:0010626)negative regulation of activin receptor signaling pathway (GO:0032926)negative regulation of cell population proliferation (GO:0008285)negative regulation of fibroblast proliferation (GO:0048147)negative regulation of osteoblast differentiation (GO:0045668)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)neural tube closure (GO:0001843)nose morphogenesis (GO:0043585)nuclear body (GO:0016604)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)olfactory bulb development (GO:0021772)positive regulation of DNA binding (GO:0043388)positive regulation of Wnt signaling pathway (GO:0030177)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein kinase binding (GO:0019901)protein-containing complex (GO:0032991)regulation of neurogenesis (GO:0050767)retina development in camera-type eye (GO:0060041)roof of mouth development (GO:0060021)skeletal muscle fiber development (GO:0048741)somatic stem cell population maintenance (GO:0035019)transcription regulator complex (GO:0005667)transcription regulator complex (GO:0005667)transcription repressor complex (GO:0017053)transforming growth factor beta receptor signaling pathway (GO:0007179)ubiquitin protein ligase binding (GO:0031625)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating SKI 0 TFs

Transcription factors with Perturb-seq knockdown data for SKI. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SKI upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SKI

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SKI, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr1:1,959,901–1,960,517	267.2 kb	Distal (>10kb) Multiome	594
	chr1:2,019,137–2,019,982	207.9 kb	Distal (>10kb) Multiome	288
	chr1:2,044,569–2,045,304	182.4 kb	Distal (>10kb) Multiome	403
	chr1:2,049,277–2,050,992	177.1 kb	Distal (>10kb) Multiome	732
	chr1:2,132,340–2,134,100	93.9 kb	Distal (>10kb) Multiome	508
	chr1:2,189,382–2,190,314	37.7 kb	Distal (>10kb) Multiome	719
	chr1:2,194,502–2,195,788	32.4 kb	Distal (>10kb) Multiome	789
	chr1:2,199,148–2,199,756	27.9 kb	Distal (>10kb) Multiome	445
	chr1:2,204,191–2,206,396	22.2 kb	Distal (>10kb) Multiome	597
	chr1:2,212,255–2,213,305	14.7 kb	Distal (>10kb) Multiome	601
	chr1:2,226,557–2,228,163	464 bp	At TSS Multiome	675
	chr1:2,228,663–2,229,617	1.3 kb	Proximal (<10kb)	480
	chr1:2,231,954–2,232,145	4.6 kb	Proximal (<10kb)	280
	chr1:2,248,086–2,248,655	21.0 kb	Distal (>10kb) Multiome	296
	chr1:2,279,142–2,279,636	52.0 kb	Distal (>10kb) Multiome	172
	chr1:2,311,328–2,311,918	84.3 kb	Distal (>10kb) Multiome HiCAR	366
	chr1:2,314,340–2,315,728	87.7 kb	Distal (>10kb) Multiome HiCAR	557
	chr1:2,391,076–2,392,400	164.3 kb	Distal (>10kb) Multiome	820
	chr1:2,411,953–2,414,836	185.3 kb	Distal (>10kb) Multiome	918
	chr1:2,525,908–2,527,142	299.0 kb	Distal (>10kb) Multiome	668

Genome Browser

Genomic view of the SKI locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.