Enables deubiquitinase activity; histone binding activity; and transcription coactivator activity. Involved in chromatin remodeling; positive regulation of transcription by RNA polymerase II; and regulation of hemopoiesis. Located in nucleolus and nucleoplasm. Part of protein-containing complex. Implicated in diabetic retinopathy. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MYSM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYSM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYSM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:58,432,643–58,433,226 | 267.1 kb | Distal (>10kb) Multiome | 176 | |
| chr1:58,447,893–58,448,830 | 251.8 kb | Distal (>10kb) Multiome | 88 | |
| chr1:58,545,902–58,547,165 | 153.3 kb | Distal (>10kb) Multiome | 808 | |
| chr1:58,576,513–58,577,828 | 122.8 kb | Distal (>10kb) Multiome | 406 | |
| chr1:58,699,577–58,700,464 | 22 bp | At TSS Multiome | 702 | |
| chr1:58,704,094–58,705,219 | 4.8 kb | Proximal (<10kb) Multiome | 154 | |
| chr1:58,782,095–58,785,778 | 84.1 kb | Distal (>10kb) Multiome | 1186 | |
| chr1:58,814,035–58,816,778 | 116.4 kb | Distal (>10kb) Multiome | 966 | |
| chr1:58,853,148–58,854,080 | 153.6 kb | Distal (>10kb) Multiome | 53 | |
| chr1:58,884,762–58,885,830 | 185.4 kb | Distal (>10kb) Multiome | 725 | |
| chr1:58,896,308–58,897,070 | 196.6 kb | Distal (>10kb) Multiome | 425 | |
| chr1:58,903,394–58,904,485 | 203.8 kb | Distal (>10kb) Multiome | 782 | |
| chr1:59,077,777–59,078,789 | 378.2 kb | Distal (>10kb) Multiome HiCAR | 361 | |
| chr1:59,296,207–59,297,834 | 596.8 kb | Distal (>10kb) Multiome HiCAR | 874 | |
| chr1:59,769,240–59,769,882 | 1069.5 kb | Distal (>10kb) Multiome HiCAR | 103 | |
| chr1:59,814,141–59,815,752 | 1114.7 kb | Distal (>10kb) Multiome HiCAR | 767 |
Genomic view of the MYSM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.