The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for NFATC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFATC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFATC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:79,246,410–79,246,885 | 149.2 kb | Distal (>10kb) Multiome | 387 | |
| chr18:79,378,841–79,379,450 | 16.8 kb | Distal (>10kb) Multiome | 268 | |
| chr18:79,393,193–79,393,548 | 2.4 kb | Proximal (<10kb) | 129 | |
| chr18:79,393,688–79,395,560 | 1.7 kb | Proximal (<10kb) Multiome | 539 | |
| chr18:79,395,691–79,396,909 | 25 bp | At TSS Multiome | 372 | |
| chr18:79,399,259–79,400,995 | 4.5 kb | Proximal (<10kb) Multiome | 361 | |
| chr18:79,506,395–79,507,651 | 111.2 kb | Distal (>10kb) Multiome | 390 | |
| chr18:79,567,133–79,567,644 | 171.4 kb | Distal (>10kb) Multiome | 54 | |
| chr18:79,600,813–79,601,925 | 205.5 kb | Distal (>10kb) Multiome | 253 | |
| chr18:79,610,922–79,611,725 | 215.3 kb | Distal (>10kb) Multiome | 353 | |
| chr18:79,678,750–79,680,983 | 283.5 kb | Distal (>10kb) Multiome | 955 |
Genomic view of the NFATC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.