The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IGF2BP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGF2BP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGF2BP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:23,181,578–23,182,460 | 288.5 kb | Distal (>10kb) Multiome | 935 | |
| chr7:23,205,915–23,206,590 | 264.2 kb | Distal (>10kb) Multiome | 154 | |
| chr7:23,247,362–23,248,065 | 222.7 kb | Distal (>10kb) Multiome | 202 | |
| chr7:23,299,105–23,299,994 | 171.2 kb | Distal (>10kb) Multiome | 852 | |
| chr7:23,465,333–23,465,840 | 5.0 kb | Proximal (<10kb) Multiome | 410 | |
| chr7:23,467,898–23,468,049 | 2.4 kb | Proximal (<10kb) | 281 | |
| chr7:23,468,151–23,470,057 | 433 bp | At TSS | 623 | |
| chr7:23,470,190–23,471,917 | 808 bp | At TSS Multiome | 922 | |
| chr7:23,473,588–23,475,134 | 4.0 kb | Proximal (<10kb) Multiome | 996 | |
| chr7:23,531,132–23,532,637 | 61.6 kb | Distal (>10kb) Multiome | 1024 | |
| chr7:23,596,997–23,598,169 | 127.0 kb | Distal (>10kb) Multiome | 879 | |
| chr7:23,679,780–23,681,279 | 209.6 kb | Distal (>10kb) Multiome | 505 | |
| chr7:23,696,878–23,697,414 | 226.7 kb | Distal (>10kb) Multiome | 334 | |
| chr7:23,723,610–23,724,568 | 253.6 kb | Distal (>10kb) Multiome | 80 |
Genomic view of the IGF2BP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.