The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for MED15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MED15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MED15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:20,203,393–20,204,086 | 292.1 kb | Distal (>10kb) Multiome | 292 | |
| chr22:20,243,636–20,244,300 | 251.9 kb | Distal (>10kb) Multiome | 251 | |
| chr22:20,267,373–20,268,700 | 227.5 kb | Distal (>10kb) Multiome | 449 | |
| chr22:20,298,366–20,300,076 | 196.7 kb | Distal (>10kb) Multiome | 538 | |
| chr22:20,319,527–20,320,815 | 175.8 kb | Distal (>10kb) Multiome | 805 | |
| chr22:20,393,744–20,394,682 | 101.8 kb | Distal (>10kb) Multiome | 854 | |
| chr22:20,418,190–20,418,662 | 77.5 kb | Distal (>10kb) Multiome | 594 | |
| chr22:20,431,567–20,432,135 | 64.1 kb | Distal (>10kb) Multiome | 135 | |
| chr22:20,437,361–20,438,451 | 58.0 kb | Distal (>10kb) Multiome | 393 | |
| chr22:20,495,029–20,496,932 | 53 bp | At TSS Multiome | 1018 | |
| chr22:20,507,376–20,507,935 | 11.7 kb | Distal (>10kb) Multiome | 894 | |
| chr22:20,606,015–20,606,540 | 110.5 kb | Distal (>10kb) Multiome | 411 | |
| chr22:20,702,218–20,703,674 | 207.1 kb | Distal (>10kb) Multiome | 438 |
Genomic view of the MED15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.